TOLUIDINE BLUE MSDS
1: Chemical Product and Company Identification
Name: Toluidine Blue O
Basic Blue 17; Tolonium
chloride; Blutene chloride; C.I. Basic Blue 17; Gabilin; Menodin
2: Composition and Information on Ingredients Composition:
CAS # % by Weight
Blue O 92-31-9 100
Data on Ingredients: Not
3: Hazards Identification
Acute Health Effects: Slightly
hazardous in case of skin contact (irritant), of eye contact (irritant), of
ingestion, of inhalation.
Chronic Health Effects:
EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
4: First Aid Measures Eye Contact:
for and remove any contact lenses. In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Cold water may be used. Get
medical attention if irritation occurs.
Contact: Wash with soap
and water. Cover the irritated skin with an emollient. Get medical attention if
irritation develops. Cold water may be used.
Skin Contact: Not
If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical attention.
Inhalation: Not available.
Do NOT induce vomiting
unless directed to do so by medical personnel. Never give anything by mouth to
an unconscious person. If large quantities of this material are swallowed, call
a physician immediately. Loosen tight clothing such as a collar, tie, belt or
Ingestion: Not available.
5: Fire and Explosion Data
of the Product: May be
combustible at high temperature.
Points: Not available.
Limits: Not available.
of Combustion: These
products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), sulfur oxides
Hazards in Presence of Various Substances: Slightly
flammable to flammable in presence of heat.
Hazards in Presence of Various Substances:
of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not
Fighting Media and Instructions:
FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not
use water jet.
Remarks on Fire Hazards: As
with most organic solids, fire is possible at elevated temperatures
Remarks on Explosion Hazards: Not
6: Accidental Release Measures Small Spill:
appropriate tools to put the spilled solid in a convenient waste disposal
container. Finish cleaning by spreading water on the contaminated surface and
dispose of according to local and regional authority requirements.
Spill: Use a shovel to put
the material into a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the
7: Handling and Storage Precautions:
away from heat. Keep away from sources of ignition. Ground all equipment
containing material. Do not breathe dust. Wear suitable protective clothing. If
you feel unwell, seek medical attention and show the label when possible. Keep
away from incompatibles such as oxidizing agents.
Keep container tightly
closed. Keep container in a cool, well-ventilated area.
8: Exposure Controls/Personal Protection Engineering Controls:
process enclosures, local exhaust ventilation, or other engineering controls to
keep airborne levels below recommended exposure limits. If user operations
generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
glasses. Lab coat. Dust respirator. Be sure to use an approved/certified
respirator or equivalent. Gloves.
Protection in Case of a Large Spill:
goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing
apparatus should be used to avoid inhalation of the product. Suggested
protective clothing might not be sufficient; consult a specialist BEFORE
handling this product.
Limits: Not available.
9: Physical and Chemical Properties
state and appearance: Solid.
Weight: 305.83 g/mole
(1% soln/water): Not
Point: Not available.
Point: Not available.
Gravity: Not available.
Pressure: Not applicable.
Density: Not available.
Threshold: Not available.
Dist. Coeff.: Not
(in Water): Not available.
Properties: See solubility
Soluble in methanol.
Partially soluble in cold water. Solubility in Water: 3.82 g/100 ml
10: Stability and Reactivity Data
The product is stable.
of Instability: Excess
heat, incompatible materials
with various substances: Reactive
with oxidizing agents.
Non-corrosive in presence
Remarks on Reactivity: Not
Remarks on Corrosivity: Not
Will not occur.
11: Toxicological Information
of Entry: Inhalation.
Not available. LC50: Not available.
Effects on Humans: MUTAGENIC
EFFECTS: Mutagenic for bacteria and/or yeast.
Toxic Effects on Humans: Slightly
hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Remarks on Toxicity to Animals: Not
Remarks on Chronic Effects on Humans: May
affect genetic material (mutagenic)
Remarks on other Toxic Effects on Humans:
Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye
irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May
cause nausea, vomiting, abdominal pain, diarrhea, dyspnea (difficulty
breathing), bluish tint of the skin. May cause burning on urination, and the
urine to become dark blue to green depending on the concentration in the urine.
There have been reports on effects of Toluidine Blue O on the blood (hemolytic
on behavior/central nervous system (headache, convulsions), cardiovascular
system (hypertension, dysrthymia) as well as reports of acute renal failure and
hematuria (only after hemolysis). However, these effects occured only after
12: Ecological Information
and COD: Not available.
hazardous short term degradation products are not likely. However, long term
degradation products may arise.
of the Products of Biodegradation: The
product itself and its products of degradation are not toxic.
Remarks on the Products of Biodegradation: Not
13: Disposal Considerations Waste Disposal:
must be disposed of in accordance with federal, state and local environmental
14: Transport Information
Classification: Not a DOT
controlled material (United States).
Provisions for Transport: Not
15: Other Regulatory Information
and State Regulations: TSCA
8(b) inventory: Toluidine Blue O
Regulations: EINECS: This
product is on the European Inventory of Existing Commercial Chemical Substances.
(Canada): Not controlled
under WHMIS (Canada).
(EEC): This product is not
classified according to the EU regulations. Not applicable.
Fire Protection Association (U.S.A.):
Disclaimer: Nile Chemicals. provides the
information contained herein in good faith but makes no representation as to its
comprehensiveness or accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly trained person
using this product. Individuals receiving the information must exercise their
independent judgment in determining its appropriateness for a particular
purpose. NILE CHEMICALS. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS
OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, NILE
CHEMICALS. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE
UPON THIS INFORMATION.
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