NILE CHEMICALS
SAFETY
DATA SHEET
1.
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1
Product identifiers
Product
name : 4-Aminoantipyrine
Product
Number :
Brand :
Nile
CAS-No.
: 83-07-8
1.2
Relevant identified uses of the substance or mixture and uses advised against
Identified
uses : Laboratory chemicals, Manufacture of substances
1.3
Details of the supplier of the safety data sheet
Company
: Nile Chemical
Masjid
Bunder Mumbai INDIA
Telephone
: 66313162
1.4
Emergency telephone number
Emergency
Phone # : +91-2266313162
2.
HAZARDS IDENTIFICATION
2.1
Classification of the substance or mixture
Classification
according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute
toxicity, Oral (Category 4)
Skin
irritation (Category 2)
Eye
irritation (Category 2)
Specific
target organ toxicity - single exposure (Category 3)
Classification
according to EU Directives 67/548/EEC or 1999/45/EC
Harmful
if swallowed. Irritating to eyes, respiratory system and skin.
2.2
Label elements
Signal
word Warning
Hazard
statement(s)
H302
Harmful if swallowed.
H315
Causes skin irritation.
H319
Causes serious eye irritation.
H335
May cause respiratory irritation.
Precautionary
statement(s)
P261
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 +
P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact
lenses, if present and easy to do. Continue rinsing.
Supplemental
Hazard none
Statements
Safety
data sheet available on request.
According
to European Directive 67/548/EEC as amended.
Hazard
symbol(s)
R-phrase(s)
R22
Harmful if swallowed.
R36/37/38
Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26 In
case of contact with eyes, rinse immediately with plenty of water and
seek
medical advice.
S36
Wear suitable protective clothing.
2.3
Other hazards - none
3.
COMPOSITION/INFORMATION ON INGREDIENTS
3.1
Substances
Synonyms
: 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
Ampyrone
Formula
: C11H13N3O
Molecular
Weight : 203,24 g/mol
Component
Concentration
4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
CAS-No. EC-No.
83-07-8
201-452-3
4.
FIRST AID MEASURES
4.1
Description of first aid measures
General
advice Consult
a physician. Show this safety data sheet to the doctor in attendance.
If
inhaled If
breathed in, move person into fresh air. If not breathing, give artificial
respiration. Consult a physician.
In
case of skin contact Wash
off with soap and plenty of water. Consult a physician.
In
case of eye contact Rinse
thoroughly with plenty of water for at least 15 minutes and consult a physician.
If
swallowed Never
give anything by mouth to an unconscious person. Rinse mouth with water. Consult
a physician.
4.2
Most important symptoms and effects, both acute and delayed
To the
best of our knowledge, the chemical, physical, and toxicological properties have
not been
thoroughly
investigated.
4.3
Indication of any immediate medical attention and special treatment needed
no data
available
5.
FIREFIGHTING MEASURES
5.1
Extinguishing media
Suitable
extinguishing media
Use
water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2
Special hazards arising from the substance or mixture
Carbon
oxides, nitrogen oxides (NOx)
5.3
Advice for firefighters
Wear
self contained breathing apparatus for fire fighting if necessary.
5.4
Further information
no data
available
6.
ACCIDENTAL RELEASE MEASURES
6.1
Personal precautions, protective equipment and emergency procedures
Use
personal protective equipment. Avoid dust formation. Avoid breathing vapors,
mist or gas. Ensure
adequate
ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
6.2
Environmental precautions
Do not
let product enter drains.
6.3
Methods and materials for containment and cleaning up
Pick up
and arrange disposal without creating dust. Sweep up and shovel. Keep in
suitable, closed
containers
for disposal.
6.4
Reference to other sections
For
disposal see section 13.
7.
HANDLING AND STORAGE
7.1
Precautions for safe handling
Avoid
contact with skin and eyes. Avoid formation of dust and aerosols.
Provide
appropriate exhaust ventilation at places where dust is formed.Normal measures
for preventive fire
protection.
7.2
Conditions for safe storage, including any incompatibilities
Store
in cool place. Keep container tightly closed in a dry and well-ventilated place.
hygroscopic
Light sensitive.
7.3
Specific end uses
no data
available
8.
EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1
Control parameters
Components
with workplace control parameters
8.2
Exposure controls
Appropriate
engineering controls
Handle
in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and
at the
end of workday.
Personal
protective equipment
Eye/face
protection
Safety
glasses with side-shields conforming to EN166 Use equipment for eye protection
tested
and
approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Skin
protection
Handle
with gloves. Gloves must be inspected prior to use. Use proper glove removal
technique
(without
touching glove's outer surface) to avoid skin contact with this product. Dispose
of
contaminated
gloves after use in accordance with applicable laws and good laboratory
practices.
Wash
and dry hands.
The
selected protective gloves have to satisfy the specifications of EU Directive
89/686/EEC and
the
standard EN 374 derived from it.
Immersion
protection
Material:
Nitrile rubber
Minimum
layer thickness: 0,11 mm
Break
through time: > 480 min
Material
tested:DermatrilŪ (Aldrich Z677272, Size M)
Splash
protection
Material:
Nitrile rubber
Minimum
layer thickness: 0,11 mm
Break
through time: > 30 min
Material
tested:DermatrilŪ (Aldrich Z677272, Size M)
data
source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail
sales@kcl.de,
test
method: EN374
If used
in solution, or mixed with other substances, and under conditions which differ
from EN 374,
contact
the supplier of the CE approved gloves. This recommendation is advisory only and
must
be
evaluated by an Industrial Hygienist familiar with the specific situation of
anticipated use by our
customers.
It should not be construed as offering an approval for any specific use
scenario.
Body
Protection
Complete
suit protecting against chemicals, The type of protective equipment must be
selected
according
to the concentration and amount of the dangerous substance at the specific
workplace.
Respiratory
protection
For
nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle
respirator.For higher
level
protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator
cartridges.
Use
respirators and components tested and approved under appropriate government
standards
such as
NIOSH (US) or CEN (EU).
9.
PHYSICAL AND CHEMICAL PROPERTIES
9.1
Information on basic physical and chemical properties
a)
Appearance Form: solid
b)
Odour no data available
c)
Odour Threshold no data available
d) pH
no data available
e)
Melting point/freezing
point
Melting
point/range: 105 - 110 °C - lit.
f)
Initial boiling point and
boiling
range
no data
available
g)
Flash point no data available
h)
Evaporation rate no data available
i)
Flammability (solid, gas) no data available
j)
Upper/lower
flammability
or
explosive
limits
no data
available
k)
Vapour pressure no data available
l)
Vapour density no data available
m)
Relative density no data available
n)
Water solubility no data available
o)
Partition coefficient: noctanol/
water
no data
available
p)
Autoignition
temperature
no data
available
q)
Decomposition
temperature
no data
available
r)
Viscosity no data available
s)
Explosive properties no data available
t)
Oxidizing properties no data available
9.2
Other safety information
no data
available
10.
STABILITY AND REACTIVITY
10.1
Reactivity
no data
available
10.2
Chemical stability
no data
available
10.3
Possibility of hazardous reactions
no data
available
10.4
Conditions to avoid
no data
available
10.5
Incompatible materials
Strong
oxidizing agents, Strong acids, Acid chlorides, Acid anhydrides
10.6
Hazardous decomposition products
Other
decomposition products - no data available
11.
TOXICOLOGICAL INFORMATION
11.1
Information on toxicological effects
Acute
toxicity
LD50
Oral - rat - 1.700 mg/kg
Inhalation:
no data available
Skin
corrosion/irritation
no data
available
Serious
eye damage/eye irritation
no data
available
Respiratory
or skin sensitization
no data
available
Germ
cell mutagenicity
Genotoxicity
in vitro - Histidine reversion (Ames)
Carcinogenicity
IARC:
No component of this product present at levels greater than or equal to 0.1% is
identified as
probable,
possible or confirmed human carcinogen by IARC.
Reproductive
toxicity
no data
available
Specific
target organ toxicity - single exposure
Inhalation
- May cause respiratory irritation.
Specific
target organ toxicity - repeated exposure
no data
available
Aspiration
hazard
no data
available
Potential
health effects
Inhalation
May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion
Harmful if swallowed.
Skin
May
be harmful if absorbed through skin. Causes skin irritation.
Eyes
Causes
serious eye irritation.
Signs
and Symptoms of Exposure
To the
best of our knowledge, the chemical, physical, and toxicological properties have
not been
thoroughly
investigated.
Additional
Information
RTECS:
CD2480000
12.
ECOLOGICAL INFORMATION
12.1
Toxicity
no data
available
12.2
Persistence and degradability
no data
available
12.3
Bioaccumulative potential
no data
available
12.4
Mobility in soil
no data
available
12.5
Results of PBT and vPvB assessment
no data
available
12.6
Other adverse effects
no data
available
13.
DISPOSAL CONSIDERATIONS
13.1
Waste treatment methods
Product
Offer
surplus and non-recyclable solutions to a licensed disposal company. Contact a
licensed
professional
waste disposal service to dispose of this material. Dissolve or mix the material
with a
combustible
solvent and burn in a chemical incinerator equipped with an afterburner and
scrubber.
Contaminated
packaging
Dispose
of as unused product.
14.
TRANSPORT INFORMATION
14.1
UN number
ADR/RID:
- IMDG: - IATA: -
14.2
UN proper shipping name
ADR/RID:
Not dangerous goods
IMDG:
Not dangerous goods
IATA:
Not dangerous goods
14.3
Transport hazard class(es)
ADR/RID:
- IMDG: - IATA: -
14.4
Packaging group
ADR/RID:
- IMDG: - IATA: -
14.5
Environmental hazards
ADR/RID:
no IMDG Marine pollutant: no IATA: no
14.6
Special precautions for user
no data
available
15.
REGULATORY INFORMATION
This
safety datasheet complies with the requirements of Regulation (EC) No.
1907/2006.
15.1
Safety, health and environmental regulations/legislation specific for the
substance or mixture
no data
available
no data
available
16.
OTHER INFORMATION
Further
information
The
above information is believed to be correct but does not purport to be all
inclusive and shall be
used
only as a guide. The information in this document is based on the present state
of our knowledge
and is
applicable to the product with regard to appropriate safety precautions. It does
not represent any
guarantee
of the properties of the product. Nile Chemicals and its Affiliates shall not be
held
liable
for any damage resulting from handling or from contact with the above product.
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