NILE
CHEMICALS
NILE
CHEMICALS
TOLUIDINE BLUE
Section
1: Chemical Product and Company Identification
Product
Name: Toluidine Blue O
CAS#:
92-31-9
CI#:
52040
Synonym:
Basic Blue 17; Tolonium
chloride; Blutene chloride; C.I. Basic Blue 17; Gabilin; Menodin
Chemical
Name: 3-Amino-7-(dimethylamino)-2-methylphenothiazin-5-ium
chloride;
Chemical
Formula: C15-H16-N3-S-Cl
Section
2: Composition and Information on Ingredients Composition:
Name
CAS # % by Weight
Toluidine
Blue O 92-31-9 100
Toxicological
Data on Ingredients: Not
applicable.
Section
3: Hazards Identification
Potential
Acute Health Effects: Slightly
hazardous in case of skin contact (irritant), of eye contact (irritant), of
ingestion, of inhalation.
Potential
Chronic Health Effects:
CARCINOGENIC
EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast.
TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Section
4: First Aid Measures Eye Contact:
Check
for and remove any contact lenses. In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Cold water may be used. Get
medical attention if irritation occurs.
Skin
Contact: Wash with soap
and water. Cover the irritated skin with an emollient. Get medical attention if
irritation develops. Cold water may be used.
Serious
Skin Contact: Not
available.
Inhalation:
If inhaled, remove to
fresh air. If not breathing, give artificial respiration. If breathing is
difficult, give oxygen. Get medical attention.
Serious
Inhalation: Not available.
Ingestion:
Do NOT induce vomiting
unless directed to do so by medical personnel. Never give anything by mouth to
an unconscious person. If large quantities of this material are swallowed, call
a physician immediately. Loosen tight clothing such as a collar, tie, belt or
waistband.
Serious
Ingestion: Not available.
Section
5: Fire and Explosion Data
Flammability
of the Product: May be
combustible at high temperature.
Auto-Ignition
Temperature: Not
available.
Flash
Points: Not available.
Flammable
Limits: Not available.
Products
of Combustion: These
products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), sulfur oxides
(SO2,SO3...).
Fire
Hazards in Presence of Various Substances: Slightly
flammable to flammable in presence of heat.
Explosion
Hazards in Presence of Various Substances:
Risks
of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not
available.
Fire
Fighting Media and Instructions:
SMALL
FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not
use water jet.
Special
Remarks on Fire Hazards: As
with most organic solids, fire is possible at elevated temperatures
Special
Remarks on Explosion Hazards: Not
available.
Section
6: Accidental Release Measures Small Spill:
Use
appropriate tools to put the spilled solid in a convenient waste disposal
container. Finish cleaning by spreading water on the contaminated surface and
dispose of according to local and regional authority requirements.
Large
Spill: Use a shovel to put
the material into a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the
sanitary system.
Section
7: Handling and Storage Precautions:
Keep
away from heat. Keep away from sources of ignition. Ground all equipment
containing material. Do not breathe dust. Wear suitable protective clothing. If
you feel unwell, seek medical attention and show the label when possible. Keep
away from incompatibles such as oxidizing agents.
Storage:
Keep container tightly
closed. Keep container in a cool, well-ventilated area.
Section
8: Exposure Controls/Personal Protection Engineering Controls:
Use
process enclosures, local exhaust ventilation, or other engineering controls to
keep airborne levels below recommended exposure limits. If user operations
generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
Personal
Protection: Safety
glasses. Lab coat. Dust respirator. Be sure to use an approved/certified
respirator or equivalent. Gloves.
Personal
Protection in Case of a Large Spill:
Splash
goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing
apparatus should be used to avoid inhalation of the product. Suggested
protective clothing might not be sufficient; consult a specialist BEFORE
handling this product.
Exposure
Limits: Not available.
Section
9: Physical and Chemical Properties
Physical
state and appearance: Solid.
(Powder.)
Odor:
Not available.
Taste:
Not available.
Molecular
Weight: 305.83 g/mole
Color:
Green. (Dark.)
pH
(1% soln/water): Not
available.
Boiling
Point: Not available.
Melting
Point: Not available.
Critical
Temperature: Not
available.
Specific
Gravity: Not available.
Vapor
Pressure: Not applicable.
Vapor
Density: Not available.
Volatility:
Not available.
Odor
Threshold: Not available.
Water/Oil
Dist. Coeff.: Not
available.
Ionicity
(in Water): Not available.
Dispersion
Properties: See solubility
in water.
Solubility:
Soluble in methanol.
Partially soluble in cold water. Solubility in Water: 3.82 g/100 ml
Section
10: Stability and Reactivity Data
Stability:
The product is stable.
Instability
Temperature: Not
available.
Conditions
of Instability: Excess
heat, incompatible materials
Incompatibility
with various substances: Reactive
with oxidizing agents.
Corrosivity:
Non-corrosive in presence
of glass.
Special
Remarks on Reactivity: Not
available.
Special
Remarks on Corrosivity: Not
available.
Polymerization:
Will not occur.
Section
11: Toxicological Information
Routes
of Entry: Inhalation.
Ingestion.
Toxicity
to Animals:
LD50:
Not available. LC50: Not available.
Chronic
Effects on Humans: MUTAGENIC
EFFECTS: Mutagenic for bacteria and/or yeast.
Other
Toxic Effects on Humans: Slightly
hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special
Remarks on Toxicity to Animals: Not
available.
Special
Remarks on Chronic Effects on Humans: May
affect genetic material (mutagenic)
Special
Remarks on other Toxic Effects on Humans:
Acute
Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye
irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May
cause nausea, vomiting, abdominal pain, diarrhea, dyspnea (difficulty
breathing), bluish tint of the skin. May cause burning on urination, and the
urine to become dark blue to green depending on the concentration in the urine.
There have been reports on effects of Toluidine Blue O on the blood (hemolytic
anemia, leukopenia,
methemoglobinemia),
on behavior/central nervous system (headache, convulsions), cardiovascular
system (hypertension, dysrthymia) as well as reports of acute renal failure and
hematuria (only after hemolysis). However, these effects occured only after
intravenous dosage.
Section
12: Ecological Information
Ecotoxicity:
Not available.
BOD5
and COD: Not available.
Products
of Biodegradation:
Possibly
hazardous short term degradation products are not likely. However, long term
degradation products may arise.
Toxicity
of the Products of Biodegradation: The
product itself and its products of degradation are not toxic.
Special
Remarks on the Products of Biodegradation: Not
available.
Section
13: Disposal Considerations Waste Disposal:
Waste
must be disposed of in accordance with federal, state and local environmental
control regulations.
Section
14: Transport Information
DOT
Classification: Not a DOT
controlled material (United States).
Identification:
Not applicable.
Special
Provisions for Transport: Not
applicable.
Section
15: Other Regulatory Information
Federal
and State Regulations: TSCA
8(b) inventory: Toluidine Blue O
Other
Regulations: EINECS: This
product is on the European Inventory of Existing Commercial Chemical Substances.
Other
Classifications:
WHMIS
(Canada): Not controlled
under WHMIS (Canada).
DSCL
(EEC): This product is not
classified according to the EU regulations. Not applicable.
HMIS
(U.S.A.):
Health
Hazard: 1
Fire
Hazard: 1
Reactivity:
0
Personal
Protection: E
National
Fire Protection Association (U.S.A.):
Health:
1
Flammability:
1
Reactivity:
0
Specific
hazard:
Disclaimer: Nile Chemicals. provides the
information contained herein in good faith but makes no representation as to its
comprehensiveness or accuracy. This document is intended only as a guide to the
appropriate precautionary handling of the material by a properly trained person
using this product. Individuals receiving the information must exercise their
independent judgment in determining its appropriateness for a particular
purpose. NILE CHEMICALS. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS
OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH
HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, NILE
CHEMICALS. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE
UPON THIS INFORMATION.
Product range
| Ph Indicator | Chemicals Lab Bulk | Catalyst | Food Colour | Herbs | Intermediates |
| Cesium Salts | Ion Pair Reagents | Direct Dyes | Contact details | Acid Dyes | Solvents |